Most-Viewed Webinar of 2025: Practical Strategies for Handling VUS in Clinical Care

Insights | 25. 12. 23

From uncertainty to action — insights from real-world practice

Key Takeaways

VUS remains one of the most challenging aspects of genetic diagnostics.
Clinicians value practical guidance on interpretation, communication, and follow-up.
Reanalysis and longitudinal thinking are central to managing uncertainty responsibly.

Variants of Uncertain Significance (VUS) remain one of the most challenging realities in genetic diagnostics. They sit in the gray zone — clinically relevant, but not yet clinically actionable — leaving clinicians to navigate uncertainty with patients, families, and care teams.

In 2025, no topic drew more engagement than this one.

Our virtual panel series, “From Ambiguity to Action: Practical Insights on Handling VUS,” became the most-viewed on-demand webinar of the year, bringing together experts across Asia and Europe to share how VUS is handled in real-world clinical practice.

Rather than focusing on theory alone, both sessions centered on what clinicians face every day:

How to interpret VUS responsibly
How to communicate uncertainty to patients and families
How reanalysis, AI, and data sharing can shift variants over time
How different regions approach the same diagnostic challenge

Across both regions, a shared theme emerged:
VUS is not the end of the diagnostic journey — it’s part of an evolving process.

Panelists discussed practical strategies for investigation, follow-up, and patient communication, alongside real examples where uncertain variants were later reclassified as pathogenic or benign through ongoing evidence and reanalysis.

By grounding uncertainty in experience — not just guidelines — these sessions resonated deeply with clinicians navigating genomic ambiguity in daily care.