3billion
dna helix
Product
3B-GENOME
Whole genome sequencing-based genetic testing service
What makes 3B-GENOME different?

The most extensive genetic test to cover whole genome

3B-GENOME detects and interprets variants based on Whole Genome Sequencing (WGS), a test technique that covers the entire human genome.

High diagnostic rate
WGS tests have the highest diagnostic rate among all the other genetic tests, and WGS tests have approximately 7-8% higher diagnostic rates than WES tests.
Structural Variation (SV) covered
WGS tests detect Structural Variations (SV), including a single exon CNV or balanced chromosomal arrangement.
Mitochondrial DNA (mtDNA) covered
WGS tests detect pathogenic variants in mtDNA having higher depth-of-coverage than WES.
UPDATED

What is the
Family Insight Test?

A premium WGS solution for families facing reproductive challenges or inherited risks.
We uncover hidden genetic causes to guide accurate diagnosis and future clinical management.

Who should consider this test?

Reproductive Loss

Uncover the hidden genetic "WHY" behind recurrent miscarriages or fetal death.

Genetic Legacy

Assess inherited risks proactively to guide informed future family planning.

Alternative Path

Provide definitive answers even when testing the affected family member is not possible.

Consanguinity

Deliver clinical clarity for individuals from high-risk consanguineous families.

Family Insight TestReview the reporting criteria and ordering process.

Download Sample Report →Order Guide →

This test is a specialized test for high-risk clinical cases.
It is NOT intended for general population carrier screening.

One Test.
Continuous Reanalysis.

New research and diagnostic advances can unlock answers.With 3billion, automatic reanalysis is included—no additional cost.

Weekly Automatic Reanalysis*
Runs continuously without manual request. Covers negative and inconclusive results.
No Additional Cost
Fully included your 3B-GENOME service—no hidden fees or extra charges.
Latest DB & AI Integration
Leverages growing disease & variant databases and continuously improving interpretation algorithms.
Notification on New Findings
Receive alerts when reanalysis identifies clinically significant results.

3billion has been providing reanalysis for 5 years.** Check out the cases diagnosed with reanalysis.

View Cases →

* Available only for cases with reanalysis consent provided during 3billion portal ordering.

** 3B-EXOME

Test Specification

  • Platform
    illumina NovaSeq X
  • Mean depth of coverage
    ~30X
  • Mitochondrial genome coverage*
    1000X
  • Read length
    150bp paired-end
  • Genome covered at 20x
    ≥ 95%**
  • Variant types
    SNV, INDEL, SV (including CNV)

    • * For the mitochondrial genome variants, the level of heteroplasmy that can be reported is ≥1%

    ** Calculation based on autosomal chromosomes

    See cases diagnosed with
    3B-GENOME

    You can consider 3B-GENOME in the following circumstances

    To examine all variants with a single test
    A single test can cover all variants, including Structural Variants.
    Showing non-specific symptoms
    When the doctor suspects a genetic disease but the disease cannot only be diagnosed with the patient's phenotypes, the patient/doctor can consider a WGS.
    Undiagnosed after a WES test
    Even after a WES-based genetic test, if disease-causing variants are still not detected, a WGS test should be considered.

    FAQs

    See more FAQs

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