Director of Clinical Genomics

About 3billion

3billion is a leading genetic diagnostic company dedicated to ending the diagnostic odyssey for children and other patients with rare genetic diseases. We are a global pioneer in AI-driven genetic diagnostics, leveraging our proprietary bioinformatics pipeline to deliver rapid, accurate Exome (ES) and Genome Sequencing (GS) tests. Having successfully served patients and physicians in over 75 countries, we are now entering a new chapter: launching our first US clinical laboratory in Austin, Texas. Joining now means founding-team ownership: you will help build our US lab's people, processes, and culture from day one, backed by a platform already delivering results worldwide. We are looking for a Director of Clinical Genomics to build and lead our US clinical genomics operations, from clinical order review through variant interpretation, reporting, and post-test consultation. If you are passionate about clinical genomics and want your daily work to directly impact the lives of children and families waiting for answers, join us. Discover more about our global impact at https://3billion.io/ (opens in a new tab)

Role Overview

As the Director of Clinical Genomics, you will serve as the vital bridge between complex genomic data, bioinformatics pipelines, and patient-centric clinical care. You will leverage your genetic counseling background to adapt, implement, and scale our parent company's existing tertiary analysis pipeline for the US market. You will be responsible for creating a cohesive, end-to-end structure for clinical order verification, genomic data analysis, clinical reporting, and provider support. This includes overseeing the review and resolution of order exceptions (such as incomplete or insufficient phenotype information) before testing begins, overseeing variant curation, optimizing automated reporting workflows, and managing a high-performing team of Variant Scientists and Genetic Counselors (GCs). This is a dynamic leadership position ideal for a genetics professional who thrives on building scalable operations and shaping the clinical voice of a high-growth diagnostic laboratory. As part of our founding team, you will shape how our US clinical genomics function works from day one, and your scope will grow as we scale. You will partner closely with our CLIA Laboratory Director, who holds final responsibility for clinical report sign-out; this role does not serve as the CLIA Laboratory Director or sign out clinical reports.

Core Responsibilities

• • Team Leadership: Hire, train, and manage a cross-functional team of Variant Scientists, Genetic Counselors, and clinical operations specialists. Drive performance metrics, foster a culture of scientific rigor, and guide career development.
• • Variant Curation & Assessment: Oversee variant interpretation, ensuring strict adherence to ACMG/AMP guidelines and regulatory standards for gene-disease validity. Serve as the primary clinical escalation point for complex or edge-case variant interpretations.
• • Clinical Order Triage & Management: Oversee the clinical review of incoming orders. Manage a team of Genetic Counselors to verify that provided clinical phenotype information is appropriate, sufficient for accurate downstream analysis, and correctly captured in the LIMS prior to testing.
• • Pipeline Adaptation & Scaling: Support optimization of the tertiary analysis pipeline, ensuring that the data pathway from VCF to final clinical report is highly scalable, efficient, and robust.
• • Clinical Strategy & Evidence Generation: Act as the primary clinical stakeholder for report design and diagnostic logic. Structure pipeline data and curation databases to seamlessly support Medical Affairs, clinical utility studies, and real-world evidence generation.
• • Reporting & Automation: Ensure report language translates complex findings into clear, actionable insights. Partner with engineering to optimize automated variant filtering, annotation, and report drafting.
• • Clinical Consultation: Establish and oversee the post-test consultation workflow. Lead a team of Genetic Counselors acting as primary clinical liaisons for ordering physicians regarding variant interpretations and next steps, including recommendations for parental and family testing.
• • Quality Assurance & Compliance: Ensure all dry-lab pipelines, reporting workflows, and consultation processes comply with CAP, CLIA, HIPAA, California CDPH, and NYSDOH regulations. Author and maintain SOPs for order intake, variant curation, and report sign-out.

Required Qualifications

• • Education: Master's degree in Genetic Counseling from an ACGC-accredited program.
• • Certification: Certified Genetic Counselor (CGC) through the American Board of Genetic Counseling (ABGC), or genetic counseling certification through the American Board of Medical Genetics and Genomics (ABMGG). Must hold, or be able to obtain, genetic counselor licensure in states where required.
• • Experience: 5+ years of experience in a clinical genomics laboratory, molecular diagnostics, or commercial genetic testing environment, including at least 2 years of direct people management experience building and leading clinical, scientific, or genetic counseling teams.
• • Variant Expertise: Deep, hands-on experience with ACMG/AMP variant classification guidelines, gene-disease validity assessments, and tools like ClinVar, HGMD, gnomAD, and OMIM.
• • Tertiary Pipeline Operations: Demonstrated experience supporting, scaling, or optimizing tertiary clinical NGS workflows (variant annotation, filtering, classification, and reporting for ES, GS, or large panels).
• • Regulatory Fluency: Working knowledge of CAP, CLIA, CDPH LFS, and NYSDOH standards as they pertain to dry-lab operations, variant interpretation, and clinical reporting.
• • Reporting & Consultation: Strong background in clinical reporting logic and providing clinical consultations to non-genetics providers.

Preferred Qualifications

• • Process Engineering: Experience partnering with engineering/bioinformatics teams to optimize software tools and data pipelines specifically for variant curation and reporting.
• • Startup Mindset: Experience in a high-growth environment, specifically in localizing or scaling existing technology infrastructure for a new market.
• • Cross-Functional Communication: Proven ability to translate clinical needs to software engineers and technical constraints to medical directors.
• • Project Management: Familiarity with Agile methodologies and tools (Jira, Confluence, Asana).
• • Pediatric Rare Disease: Experience with pediatric ES/GS, including trio analysis, de novo variant assessment, and phenotype-driven (HPO) case review.

Why Join Us? (Compensation & Benefits)

We offer a competitive compensation package and, through a US Professional Employer Organization (PEO), comprehensive benefits:

• • Medical, Dental, and Vision coverage for you and your family
• • 401(k) retirement plan
• • PTO, paid sick leave, and company holidays
• • Full-coverage medical malpractice (professional liability) insurance

3billion US, Inc. is an Equal Opportunity Employer. We consider all qualified applicants without regard to race, color, religion, sex (including pregnancy), sexual orientation, gender identity, national origin, age, disability, genetic information, veteran status, or any other characteristic protected by law.

If you need a reasonable accommodation to apply or interview, contact jobs@3billion.io.

Employment offers are contingent on a background check, conducted after a conditional offer and in accordance with applicable law, including the Fair Credit Reporting Act. The check includes verification of education, licensure, and certifications.