Clinical Laboratory Technologist (Molecular Genetics)

About 3billion

3billion is a leading genetic diagnostic company dedicated to ending the diagnostic odyssey for children and other patients with rare genetic diseases. We are a global pioneer in AI-driven genetic diagnostics, leveraging our proprietary bioinformatics pipeline to deliver rapid, accurate Exome (ES) and Genome Sequencing (GS) tests. Having successfully served patients and physicians in over 75 countries, we are now entering a new chapter: launching our first US clinical laboratory in Austin, Texas. Joining now means founding-team ownership: you will help build our US lab's people, processes, and culture from day one, backed by a platform already delivering results worldwide. We are looking for a dedicated and meticulous Clinical Laboratory Technologist to be the hands-on force behind our diagnostic engine. If you are passionate about molecular biology and want your daily work at the bench to directly impact the lives of children and families waiting for answers, join us. Discover more about our global impact at https://3billion.io/ (opens in a new tab)

Role Overview

As a Clinical Laboratory Technologist, you will be the crucial frontline of our Austin lab operations, reporting directly to the Clinical Laboratory Manager. You will support the entire lifecycle of patient samples from initial receipt to high-throughput sequencing. At launch, this role combines sample accessioning with bench testing; as volume grows, accessioning may move to a dedicated team. Your work is the foundation of our diagnostic process. By ensuring careful sample intake, precise extractions, and high-quality sequencing execution, you directly contribute to the delivery of accurate patient results. You will work with state-of-the-art sequencing technology and automated liquid handling systems to process ES, GS, and Sanger sequencing-based tests. This role requires exceptional attention to detail, a strong foundation in molecular biology techniques, and a steadfast commitment to maintaining our rigorous CAP/CLIA quality standards in a fast-paced startup environment. As part of our founding lab team, you will help shape how the lab works day to day, and your responsibilities will grow with the lab.

Core Responsibilities

• • Sample Accessioning & Workflow Coordination: Receive and accurately accession samples and orders into LIS, LIMS, and other laboratory databases, ensuring fully traceable sample tracking. Triage and seamlessly transition specimens into the wet-lab pipeline, communicating proactively with providers to resolve specimen issues (labeling, volume, shipping, sample integrity).
• • Nucleic Acid Extraction & Sample Processing: Perform high-quality DNA extractions from various sample types, including low-input pediatric specimens such as buccal swabs, saliva, and small-volume blood draws, ensuring strict adherence to Standard Operating Procedures (SOPs) and quality control metrics.
• • NGS Library Preparation & Sequencing: Execute ES and GS library preparation protocols, as well as Sanger sequencing. Load, operate, and maintain high-throughput Illumina sequencing instruments and automated liquid handling systems.
• • Quality & Equipment Management: Perform daily QA/QC procedures on clinical samples and reagents. Calibrate, operate, and maintain sophisticated laboratory equipment to sustain testing throughput and reliability.
• • Safety & Regulatory Compliance: Maintain meticulous and accurate laboratory documentation. Adhere to strict safety protocols for handling biohazards and chemicals while ensuring the lab remains continuously compliant with CAP, CLIA, and HIPAA regulations.
• • Team Collaboration: Work closely with the laboratory team to identify workflow bottlenecks, assist in troubleshooting assay performance, and help maintain an organized, efficient, and well-stocked laboratory environment.

Required Qualifications

• • Education: Bachelor's degree or higher from an accredited college or university in a biological science, clinical/medical laboratory science, medical technology, or a field related to genetics (e.g., Molecular Biology, Genetics, Biology, Medical Laboratory Science), or qualifications meeting California CLS academic requirements. Degrees earned outside the U.S. require a NACES or AICE course-by-course evaluation.
  • • Regulatory role: For specimens originating in California, the candidate's qualifications must be equivalent to those required for California CGMBS or CLS licensure. California license not required.
• • Experience: 1+ years of post-baccalaureate work experience in clinical genetic molecular biology (high-complexity molecular genetic/genomic testing) in a CLIA-certified clinical laboratory, or completion of a CDPH-approved CGMBS training program. Research, academic, biotech/pharmaceutical, or infectious-disease-only testing experience does not qualify.
• • Technical Skills: Proficiency in fundamental molecular biology techniques (precise pipetting, nucleic acid extraction). Familiarity with laboratory information systems (LIMS) and sample tracking.
• • Core Traits: Exceptional attention to detail, strong organizational skills, and the ability to focus in a fast-paced, high-volume environment while handling sensitive clinical specimens.

Preferred Qualifications

• • NGS & Automation Experience: Direct, hands-on experience with NGS library preparation (ES/GS), Illumina sequencing platforms, and operating/troubleshooting automated liquid handling systems (e.g., Hamilton, Tecan).
• • Certification: MB(ASCP) certification or a California CLS or CGMBS license is a strong plus.
• • Pediatric Specimens: Experience processing pediatric or low-input specimens.

Why Join Us? (Compensation & Benefits)

We offer a competitive compensation package and, through a US Professional Employer Organization (PEO), comprehensive benefits:

• • Medical, Dental, and Vision coverage for you and your family
• • 401(k) retirement plan
• • PTO, paid sick leave, and company holidays

3billion US, Inc. is an Equal Opportunity Employer. We consider all qualified applicants without regard to race, color, religion, sex (including pregnancy), sexual orientation, gender identity, national origin, age, disability, genetic information, veteran status, or any other characteristic protected by law.

If you need a reasonable accommodation to apply or interview, contact jobs@3billion.io.

Employment offers are contingent on a background check, conducted after a conditional offer and in accordance with applicable law, including the Fair Credit Reporting Act. The check includes verification of education, licensure, and certifications.