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Variants found in patients are classified into five stages, according to 28 rules from the ACMG/AMP Standards and Guidelines, as follows:

• Pathogenic (P): When there is a known variant that is associated with the symptoms
• Likely pathogenic (LP) – When there is a known variant that is likely associated with the symptom
• Variants of unknown significance (VUS) – When there is a variant but there is insufficient evidence of pathogenicity
• Likely benign (LB) – When there is a highly benign variant
• Benign (B) – When there is a known benign variant

You can find more detailed information on variant classification in the ACMG/AMP Standards and Guidelines.