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ULBP2

Synonyms
ALCAN-alpha, N2DL2, NKG2DL2, RAET1H, RAET1L
External resources
Summary
This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
22,774
Likely benign
1,324
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on ULBP2 gene.

Phenotype class
Patients in 3billion (%)

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