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TFPI2

Synonyms
PP5, REF1, TFPI-2
External resources
Summary
This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
1,549
Likely benign
4,767
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on TFPI2 gene.

Phenotype class
Patients in 3billion (%)

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