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RND3

Synonyms
ARHE, Rho8, RhoE, memB
External resources
Summary
This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
15,890
Likely benign
476
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on RND3 gene.

Phenotype class
Patients in 3billion (%)

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