Home > Gene Browser > POLR2I

POLR2I

Synonyms
RPB9, hRPB14.5
External resources
Summary
This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
3,265
Likely benign
802
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on POLR2I gene.

Phenotype class
Patients in 3billion (%)

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