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NPFFR2

Synonyms
GPR74, HLWAR77, NPFF2, NPGPR
External resources
Summary
This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of the opioid system. Alternative splicing results in multiple transcript variants.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
1,737
Likely benign
639
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on NPFFR2 gene.

Phenotype class
Patients in 3billion (%)

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