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NFYC

Synonyms
CBF-C, CBFC, H1TF2A, HAP5, HSM, NF-YC
External resources
Summary
This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
2,727
Likely benign
990
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on NFYC gene.

Phenotype class
Patients in 3billion (%)

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