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NDRG4

Synonyms
BDM1, SMAP-8, SMAP8
External resources
Summary
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
8,863
Likely benign
8,365
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on NDRG4 gene.

Phenotype class
Patients in 3billion (%)

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