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FRAT1

Synonyms
-
External resources
Summary
The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
821
Likely benign
227
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on FRAT1 gene.

Phenotype class
Patients in 3billion (%)

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