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FOLR3

Synonyms
FR-G, FR-gamma, FRgamma, gamma-hFR
External resources
Summary
This gene encodes a member of the folate receptor (FOLR) family of proteins, which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Expression of this gene may be elevated in ovarian and primary peritoneal carcinoma. This gene is present in a gene cluster on chromosome 11. Alternative splicing results in multiple transcript variants.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
1,482
Likely benign
1,626
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on FOLR3 gene.

Phenotype class
Patients in 3billion (%)

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