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AKR1B10

Synonyms
AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI
External resources
Summary
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
2,837
Likely benign
1,269
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on AKR1B10 gene.

Phenotype class
Patients in 3billion (%)

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