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ZMAT3

Synonyms
PAG608, WIG-1, WIG1
External resources
Summary
This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
683
Likely benign
57
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on ZMAT3 gene.

Phenotype class
Patients in 3billion (%)

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