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YAP1

Synonyms
COB1, YAP, YAP2, YAP65, YKI
External resources
Summary
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms.

Variant Counts

Variant classification counts, according to ACMG guideline on all identified variants among our tested samples, are listed. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc.) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
415
Likely benign
6,164
Benign
419

Patient Phenotypes

No patients carry pathogenic or likely pathogenic variants on YAP1 gene.

Phenotype class
Patients in 3billion (%)

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