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TRIP6

Synonyms
OIP-1, OIP1, TRIP-6, TRIP6i2, ZRP-1
External resources
Summary
This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
6,872
Likely benign
1,549
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on TRIP6 gene.

Phenotype class
Patients in 3billion (%)

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