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TRIM35

Synonyms
HLS5, MAIR
External resources
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified.

Variant Counts

Variant classification counts, according to ACMG guideline on all identified variants among our tested samples, are listed. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc.) are excluded.

Pathogenic
13
Likely pathogenic
0
VUS
3,817
Likely benign
21
Benign
0

Patient Phenotypes

Proportions of phenotypes among 13 patients carrying pathogenic or likely pathogenic variants on TRIM35 gene are displayed below. The following symptoms were found in patients with a variant in TRIM35. However, patients may have been diagnosed with a different variant.

Phenotype class
Patients in 3billion (%)
Abnormality of the cardiovascular system
46.2%
Abnormality of head or neck
30.8%
Abnormality of the nervous system
30.8%
Abnormality of the ear
23.1%
Abnormality of metabolism homeostasis
15.4%
Abnormality of the genitourinary system
15.4%
Abnormality of the musculoskeletal system
15.4%
Abnormality of blood and blood forming tissues
7.7%
Abnormality of limbs
7.7%
Abnormality of the breast
7.7%
Abnormality of the eye
7.7%
Abnormality of the integument
7.7%
Growth abnormality
7.7%
Abnormal cellular phenotype
0%
Abnormality of prenatal development or birth
0%
Abnormality of the digestive system
0%
Abnormality of the endocrine system
0%
Abnormality of the immune system
0%
Abnormality of the respiratory system
0%
Abnormality of the thoracic cavity
0%
Abnormality of the voice
0%
Constitutional symptom
0%
Neoplasm
0%

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