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TPBG

Synonyms
5T4, 5T4AG, M6P1, WAIF1
External resources
Summary
This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
1,063
Likely benign
55
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on TPBG gene.

Phenotype class
Patients in 3billion (%)

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