Home > Gene Browser > TNFSF12-TNFSF13

TNFSF12-TNFSF13

Synonyms
TWE-PRIL
External resources
Summary
This gene encodes a member of the tumor necrosis factor superfamily. It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of family member 12 fused to the C-terminal domain of family member 13. The hybrid protein is membrane anchored and presents the receptor-binding domain of family member 13 at the cell surface. It stimulates cycling in T- and B-lymphoma cell lines.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
7,577
Likely benign
908
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on TNFSF12-TNFSF13 gene.

Phenotype class
Patients in 3billion (%)

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