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TIGIT

Synonyms
VSIG9, VSTM3, WUCAM
External resources
Summary
This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
2,374
Likely benign
1,679
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on TIGIT gene.

Phenotype class
Patients in 3billion (%)

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