Home > Gene Browser > TCF7L1

TCF7L1

Synonyms
TCF-3, TCF3
External resources
Summary
This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
16,430
Likely benign
936
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on TCF7L1 gene.

Phenotype class
Patients in 3billion (%)

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