Home > Gene Browser > TBC1D25

TBC1D25

Synonyms
MG81, OATL1
External resources
Summary
This gene encodes a protein with a TBC domain and functions as a Rab GTPase activating protein. The encoded protein is involved in the fusion of autophagosomes with endosomes and lysosomes. This gene was previously known as ornithine aminotransferase-like 1, but has no similarity to ornithine aminotransferase.

Variant Counts

Variant classification counts, according to ACMG guideline on all identified variants among our tested samples, are listed. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc.) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
1,509
Likely benign
249
Benign
0

Patient Phenotypes

No patients carry pathogenic or likely pathogenic variants on TBC1D25 gene.

Phenotype class
Patients in 3billion (%)

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