Home > Gene Browser > SRM

SRM

Synonyms
PAPT, SPDSY, SPS1, SRML1
External resources
Summary
The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
26,607
Likely benign
9,398
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on SRM gene.

Phenotype class
Patients in 3billion (%)

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