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RNF11

Synonyms
CGI-123, SID1669
External resources
Summary
The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN).

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
468
Likely benign
22
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on RNF11 gene.

Phenotype class
Patients in 3billion (%)

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