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RGMB

Synonyms
DRAGON
External resources
Summary
RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005

Variant Counts

Variant classification counts, according to ACMG guideline on all identified variants among our tested samples, are listed. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc.) are excluded.

Pathogenic
0
Likely pathogenic
73
VUS
1,140
Likely benign
196
Benign
0

Patient Phenotypes

Proportions of phenotypes among 73 patients carrying pathogenic or likely pathogenic variants on RGMB gene are displayed below. The following symptoms were found in patients with a variant in RGMB. However, patients may have been diagnosed with a different variant.

Phenotype class
Patients in 3billion (%)
Abnormality of the nervous system
56.2%
Abnormality of the musculoskeletal system
47.9%
Abnormality of head or neck
34.2%
Abnormality of the eye
28.8%
Abnormality of the integument
21.9%
Abnormality of limbs
17.8%
Abnormality of the ear
15.1%
Growth abnormality
13.7%
Abnormality of the genitourinary system
12.3%
Abnormality of metabolism homeostasis
8.2%
Abnormality of the cardiovascular system
8.2%
Abnormality of the endocrine system
8.2%
Abnormality of the respiratory system
6.8%
Abnormality of the digestive system
5.5%
Abnormality of the immune system
5.5%
Abnormality of blood and blood forming tissues
4.1%
Abnormality of prenatal development or birth
1.4%
Constitutional symptom
1.4%
Abnormal cellular phenotype
0%
Abnormality of the breast
0%
Abnormality of the thoracic cavity
0%
Abnormality of the voice
0%
Neoplasm
0%

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