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OR10G9

Synonyms
OR10G10P
External resources
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Variant counts

Variant classification counts according to ACMG guideline on all identified variants among our tested samples are listed. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
35
Likely pathogenic
0
VUS
2,373
Likely benign
379
Benign
0

Patient phenotypes

Proportions of phenotypes among 27 patients carring pathogenic or likely pathogenic variants on OR10G9 gene are displayed below.

Phenotype class
Patients in 3billion (%)
Abnormality of the nervous system
51.9%
Abnormality of the eye
33.3%
Abnormality of the musculoskeletal system
29.6%
Abnormality of head or neck
14.8%
Growth abnormality
14.8%
Abnormality of limbs
7.4%
Abnormality of the genitourinary system
7.4%
Abnormality of blood and blood-forming tissues
3.7%
Abnormality of the breast
3.7%
Abnormality of the cardiovascular system
3.7%
Abnormality of the digestive system
3.7%
Abnormality of the ear
3.7%
Abnormality of the endocrine system
3.7%
Abnormal cellular phenotype
0%
Abnormality of metabolism homeostasis
0%
Abnormality of prenatal development or birth
0%
Abnormality of the immune system
0%
Abnormality of the integument
0%
Abnormality of the respiratory system
0%
Abnormality of the thoracic cavity
0%
Abnormality of the voice
0%
Constitutional symptom
0%
Neoplasm
0%

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