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ONECUT1

Synonyms
HNF-6, HNF6, HNF6A
External resources
Summary
This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
788
Likely benign
1,348
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on ONECUT1 gene.

Phenotype class
Patients in 3billion (%)

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