Home > Gene Browser > MORC3
MORC3
- Synonyms
- NXP2, ZCW5, ZCWCC3
- External resources
- NCBI23515
- OMIM610078
- EnsemblENSG00000159256
- HGNCHGNC:23572
- Summary
- This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms.
Variant counts
The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.
- Pathogenic
- 4
- Likely pathogenic
- 0
- VUS
- 10,351
- Likely benign
- 2,331
- Benign
- 0
Patient phenotypes
Proportions of phenotypes among 4 patients carrying pathogenic or likely pathogenic variants on MORC3 gene are displayed below.
- Phenotype class
- Patients in 3billion (%)
- Abnormality of prenatal development or birth
- 25%
- Abnormality of the ear
- 25%
- Abnormality of the musculoskeletal system
- 25%
- Abnormality of the nervous system
- 25%
- Abnormal cellular phenotype
- 0%
- Abnormality of blood and blood-forming tissues
- 0%
- Abnormality of head or neck
- 0%
- Abnormality of limbs
- 0%
- Abnormality of metabolism homeostasis
- 0%
- Abnormality of the breast
- 0%
- Abnormality of the cardiovascular system
- 0%
- Abnormality of the digestive system
- 0%
- Abnormality of the endocrine system
- 0%
- Abnormality of the eye
- 0%
- Abnormality of the genitourinary system
- 0%
- Abnormality of the immune system
- 0%
- Abnormality of the integument
- 0%
- Abnormality of the respiratory system
- 0%
- Abnormality of the thoracic cavity
- 0%
- Abnormality of the voice
- 0%
- Constitutional symptom
- 0%
- Growth abnormality
- 0%
- Neoplasm
- 0%
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