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MORC1

Synonyms
CT33, MORC, ZCW6
External resources
Summary
This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
4,662
Likely benign
4,191
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on MORC1 gene.

Phenotype class
Patients in 3billion (%)

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