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MLX

Synonyms
MAD7, MXD7, TCFL4, TF4, bHLHd13
External resources
Summary
The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Variant Counts

Variant classification counts, according to ACMG guideline on all identified variants among our tested samples, are listed. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc.) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
2,418
Likely benign
531
Benign
0

Patient Phenotypes

No patients carry pathogenic or likely pathogenic variants on MLX gene.

Phenotype class
Patients in 3billion (%)

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