Home > Gene Browser > LRRC3B

LRRC3B

Synonyms
LRP15
External resources
Summary
The protein encoded by this gene is a tumor suppressor, with lowered expression levels found in gastric, renal, colorectal, lung, and breast cancer tissues. The promoter of this gene is frequently hypermethylated in these cancer tissues, although the hypermethylation does not appear to be the cause of the reduced expression of this gene. Several transcript variants encoding the same protein have been found for this gene.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
367
Likely benign
84
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on LRRC3B gene.

Phenotype class
Patients in 3billion (%)

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