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KNDC1

Synonyms
C10orf23, RASGEF2, Very-KIND, bB439H18.3, v-KIND
External resources
Summary
The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing that this gene could potentially be targeted by anti-aging therapies.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
40,191
Likely benign
19,352
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on KNDC1 gene.

Phenotype class
Patients in 3billion (%)

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