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KLF10

Synonyms
EGR-alpha, EGRA, TIEG, TIEG1
External resources
Summary
This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
2,235
Likely benign
806
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on KLF10 gene.

Phenotype class
Patients in 3billion (%)

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