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HS3ST4

Synonyms
3-OST-4, 30ST4, 3OST4, h3-OST-4
External resources
Summary
This gene encodes the enzyme heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4. This enzyme generates 3-O-sulfated glucosaminyl residues in heparan sulfate. Cell surface heparan sulfate is used as a receptor by herpes simplex virus type 1 (HSV-1), and expression of this gene is thought to play a role in HSV-1 pathogenesis.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
3,910
Likely benign
225
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on HS3ST4 gene.

Phenotype class
Patients in 3billion (%)

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