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GPR32

Synonyms
RVDR1
External resources
Summary
This gene is intronless and encodes a member of the G-protein coupled receptor 1 family. The encoded protein binds to resolvin D1 and lipoxin A4 and has been linked to pulmonary inflammation. A related pseudogene has been identified on chromosome 19.

Variant Counts

Variant classification counts, according to ACMG guideline on all identified variants among our tested samples, are listed. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc.) are excluded.

Pathogenic
37
Likely pathogenic
0
VUS
3,797
Likely benign
391
Benign
0

Patient Phenotypes

Proportions of phenotypes among 21 patients carrying pathogenic or likely pathogenic variants on GPR32 gene are displayed below. The following symptoms were found in patients with a variant in GPR32. However, patients may have been diagnosed with a different variant.

Phenotype class
Patients in 3billion (%)
Abnormality of the eye
57.1%
Abnormality of the nervous system
38.1%
Abnormality of the musculoskeletal system
23.8%
Abnormality of head or neck
19%
Growth abnormality
19%
Abnormality of the digestive system
14.3%
Abnormality of the endocrine system
14.3%
Abnormality of the cardiovascular system
9.5%
Neoplasm
9.5%
Abnormality of metabolism homeostasis
4.8%
Abnormality of the ear
4.8%
Abnormality of the genitourinary system
4.8%
Abnormality of the integument
4.8%
Abnormality of the voice
4.8%
Abnormal cellular phenotype
0%
Abnormality of blood and blood forming tissues
0%
Abnormality of limbs
0%
Abnormality of prenatal development or birth
0%
Abnormality of the breast
0%
Abnormality of the immune system
0%
Abnormality of the respiratory system
0%
Abnormality of the thoracic cavity
0%
Constitutional symptom
0%

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