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ELF4

Synonyms
ELFR, MEF
External resources
Summary
The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the same protein have been found for this gene.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
8,296
Likely benign
10,056
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on ELF4 gene.

Phenotype class
Patients in 3billion (%)

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