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E2F8

Synonyms
E2F-8
External resources
Summary
This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
1,544
Likely benign
1,545
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on E2F8 gene.

Phenotype class
Patients in 3billion (%)

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