Home > Gene Browser > DPP7

DPP7

Synonyms
DPP2, DPPII, QPP
External resources
Summary
The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH.

Variant Counts

Variant classification counts, according to ACMG guideline on all identified variants among our tested samples, are listed. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc.) are excluded.

Pathogenic
73
Likely pathogenic
0
VUS
5,016
Likely benign
154
Benign
0

Patient Phenotypes

Proportions of phenotypes among 73 patients carrying pathogenic or likely pathogenic variants on DPP7 gene are displayed below. The following symptoms were found in patients with a variant in DPP7. However, patients may have been diagnosed with a different variant.

Phenotype class
Patients in 3billion (%)
Abnormality of the nervous system
35.6%
Abnormality of the musculoskeletal system
26%
Abnormality of the cardiovascular system
19.2%
Abnormality of head or neck
17.8%
Abnormality of the eye
17.8%
Abnormality of the ear
16.4%
Growth abnormality
16.4%
Abnormality of the genitourinary system
13.7%
Abnormality of the immune system
12.3%
Abnormality of metabolism homeostasis
11%
Abnormality of limbs
8.2%
Abnormality of the integument
8.2%
Neoplasm
8.2%
Abnormality of the digestive system
6.8%
Abnormality of blood and blood forming tissues
5.5%
Abnormality of prenatal development or birth
4.1%
Abnormality of the respiratory system
4.1%
Constitutional symptom
4.1%
Abnormality of the endocrine system
1.4%
Abnormality of the voice
1.4%
Abnormal cellular phenotype
0%
Abnormality of the breast
0%
Abnormality of the thoracic cavity
0%

Have a question or need assistance? Ask here.

Send us your questions or comments related to the variant counts and/or patient phenotypes.