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DNAJB8

Synonyms
CT156, DJ6
External resources
Summary
The protein encoded by this gene belongs to the DNAJ/HSP40 family of proteins that regulate chaperone activity. This family member suppresses aggregation and toxicity of polyglutamine proteins, and the C-terminal tail is essential for this activity. It has been implicated as a cancer-testis antigen and as a cancer stem-like cell antigen involved in renal cell carcinoma.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
865
Likely benign
1,096
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on DNAJB8 gene.

Phenotype class
Patients in 3billion (%)

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