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CT45A5

Synonyms
CT45-3, CT45-4, CT45-6, CT45.5, CT455, CT45A3, CT45A4, CT45A6, CT45A7
External resources
Summary
This gene represents one of a cluster of several similar genes located on the q arm of chromosome X. The genes in this cluster encode members of the cancer/testis (CT) family of antigens, and are distinct from other CT antigens. These antigens are thought to be novel therapeutic targets for human cancers. Alternative splicing results in multiple transcript variants.

Variant counts

Variant classification counts according to ACMG guideline on all identified variants among our tested samples are listed. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
13
Likely pathogenic
0
VUS
490
Likely benign
167
Benign
0

Patient phenotypes

Proportions of phenotypes among 13 patients carring pathogenic or likely pathogenic variants on CT45A5 gene are displayed below.

Phenotype class
Patients in 3billion (%)
Abnormality of the eye
46.2%
Abnormality of the nervous system
46.2%
Abnormality of head or neck
38.5%
Abnormality of the ear
30.8%
Abnormality of the cardiovascular system
15.4%
Abnormality of the integument
15.4%
Abnormality of blood and blood-forming tissues
7.7%
Abnormality of limbs
7.7%
Abnormality of the digestive system
7.7%
Abnormality of the genitourinary system
7.7%
Abnormality of the immune system
7.7%
Abnormality of the musculoskeletal system
7.7%
Growth abnormality
7.7%
Abnormal cellular phenotype
0%
Abnormality of metabolism homeostasis
0%
Abnormality of prenatal development or birth
0%
Abnormality of the breast
0%
Abnormality of the endocrine system
0%
Abnormality of the respiratory system
0%
Abnormality of the thoracic cavity
0%
Abnormality of the voice
0%
Constitutional symptom
0%
Neoplasm
0%

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