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CGA

Synonyms
CG-ALPHA, FSHA, GPA1, GPHA1, GPHa, HCG, LHA, TSHA
External resources
Summary
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene.

Variant counts

Variant classification counts according to ACMG guideline on all identified variants among our tested samples are listed. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
1,367
Likely benign
1,067
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on CGA gene.

Phenotype class
Patients in 3billion (%)

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