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AURKA

Synonyms
AIK, ARK1, AURA, BTAK, PPP1R47, STK15, STK6, STK7
External resources
Summary
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
18,252
Likely benign
830
Benign
1,060

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on AURKA gene.

Phenotype class
Patients in 3billion (%)

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