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AKT2

Synonyms
HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA
External resources
Summary
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains, which is involved in signaling pathways. The gene serves as an oncogene in the tumorigenesis of cancer cells For example, its overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins, and has also been implicated in insulin signaling.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
822
Likely benign
980
Benign
2,445

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on AKT2 gene.

Phenotype class
Patients in 3billion (%)

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