Home > Gene Browser > ZNF41

ZNF41

Synonyms
MRX89
External resources
Summary
This gene encodes a protein that contains KRAB-A and KRAB-B domains multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. An initial study suggested that this gene may be associated with X-linked cognitive disability, but a later study has called this finding into question (PMID:23871722).

Variant counts

Variant classification counts according to ACMG guideline on all identified variants among our tested samples are listed. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
23
Likely pathogenic
0
VUS
1,189
Likely benign
139
Benign
0

Patient phenotypes

Proportions of phenotypes among 23 patients carring pathogenic or likely pathogenic variants on ZNF41 gene are displayed below.

Phenotype class
Patients in 3billion (%)
Abnormality of the eye
39.1%
Abnormality of the musculoskeletal system
39.1%
Abnormality of the nervous system
34.8%
Abnormality of head or neck
30.4%
Abnormality of limbs
17.4%
Abnormality of the cardiovascular system
13%
Growth abnormality
13%
Abnormality of the ear
8.7%
Abnormality of the endocrine system
8.7%
Abnormality of the integument
8.7%
Abnormality of the breast
4.3%
Abnormality of the digestive system
4.3%
Abnormality of the genitourinary system
4.3%
Neoplasm
4.3%
Abnormal cellular phenotype
0%
Abnormality of blood and blood-forming tissues
0%
Abnormality of metabolism homeostasis
0%
Abnormality of prenatal development or birth
0%
Abnormality of the immune system
0%
Abnormality of the respiratory system
0%
Abnormality of the thoracic cavity
0%
Abnormality of the voice
0%
Constitutional symptom
0%

Have a question or need assistance? Ask here.

Send us your questions or comments related to the variant counts and/or patient phenotypes