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ZIC1

Synonyms
BAIDCS, CRS6, ZIC, ZNF201
External resources
Summary
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
437
Likely benign
503
Benign
911

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on ZIC1 gene.

Phenotype class
Patients in 3billion (%)

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