Home > Gene Browser > ZFAT

ZFAT

Synonyms
AITD3, ZFAT1, ZNF406
External resources
Summary
This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
10,508
Likely benign
4,836
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on ZFAT gene.

Phenotype class
Patients in 3billion (%)

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