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ULBP3

Synonyms
N2DL-3, NKG2DL3, RAET1N
External resources
Summary
The protein encoded by this gene is one of several related ligands of the KLRK1/NKG2D receptor, which is found in primary NK cells. Binding of these ligands to the receptor activates several signal transduction pathways, including the JAK2, STAT5, and ERK pathways. The encoded protein is expressed solubly and on the surface of many tumor cells, making it potentially an important target for therapeutics.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
1,420
Likely benign
481
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on ULBP3 gene.

Phenotype class
Patients in 3billion (%)

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