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SLPI

Synonyms
ALK1, ALP, BLPI, HUSI, HUSI-I, MPI, WAP4, WFDC4
External resources
Summary
This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. This antimicrobial protein has antibacterial, antifungal and antiviral activity.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
270
Likely benign
533
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on SLPI gene.

Phenotype class
Patients in 3billion (%)

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